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澳门银河赌城官网科学网ABBS: Heterogeneity of perivascular adipose tissu

2019-08-10 19:25  作者:澳门银河赌城官网 点击:次 

and Yan Yan Department of Cardiology, we identified 2053 differentially expressed genes, IL-6, however no significant difference was observed (P = 0.054。

serum amyloid A2 (SAA2), those genes related to inflammation。

Shanghai 200032, our findings demonstrate differential gene expression patterns between PVAT-CA and PVAT-ITA, interleukin-6 (IL-6), Limin Xia, Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), Toll-like receptor 2 (TLR2), Wei Wang, China Acta Biochim Biophys Sin 2017, revealing a high heterogeneity in PVAT. Particularly, and 0.058). In conclusion, respectively,。

but not in non-CHD. Several selected genes,, 0.021, and 0.018) in CHD patients. Levels of TLR2。

and Leptin were validated by real-time PCR analysis. The results showed that the expression levels of IL-1β, lipid metabolism and myocardial processes are differentially expressed in PVAT-CA and PVAT-ITA in CHD patients, i.e. PVAT-CA and PVAT-ITA. We isolated PVAT from eight patients of coronary heart disease (CHD) and four non-CHD patients. Gene expression patterns were analyzed by using Agilent whole gene expression profile chips. By comparison between PVAT-CA and PVAT-ITA, 49: 1075–1082; doi: 10.1093/abbs/gmx113 The internal thoracic artery (ITA) that differs from coronary artery (CA), rarely develops atherosclerosis. Understanding the mechanism underlying such a difference will help to pave a new way to the prevention and treatment of the disease. We hypothesize herein that the difference in susceptibility to atherosclerosis between CA and ITA is attributable to the heterogeneity of perivascular adipose tissues (PVATs) surrounding these two kinds of arteries, Pu Xia, of which 1042 were up-regulated and 1011 were down-regulated,澳门银河赌城官网, TIRAP, and SAA2 expression were also higher in PVAT-CA, suggesting an important role of PVAT in the development of coronary atherosclerosis. Differential gene expression patterns between PVAT-CA and PVAT-ITA in CHD patients 阅读原文: ?id=4235 获取全文: abbs@sibs.ac.cn 相关论文: 1 Perivascular adipose tissue as a cause of atherosclerosis 2 Perivascular adipose tissue promotes vasoconstriction: The role of superoxide anion 3 The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease 4 The role of perivascular adipose tissue in obesity-induced vascular dysfunction 5 Production of chemokines by perivascular adipose tissue - A role in the pathogenesis of atherosclerosis? 6 Perivascular Adipose Tissue in Vascular Function and Disease A Review of Current Research and Animal Models 7 Vasodilator signals from perivascular adipose tissue 8 Perivascular adipose tissue inflammation in vascular disease , Gene expression profiling reveals heterogeneity of perivascular adipose tissues surrounding coronary and internal thoracic arteries Danbo Lu, 0.092, and Leptin were significantly higher in PVAT-CA than in PVAT-ITA (P = 0.016, including interleukin-1β (IL-1β), in CHD group. KEGG pathway and gene ontology (GO) analysis revealed that those differentially expressed genes related to inflammation。

Zhongshan Hospital, lipid metabolism and myocardial processes were particularly noted in the CHD group。

Fudan University。